SCHEMBL4355212

SCHEMBL4355212

O[C@@H](Cc1ccccc1)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.58
KDM4E B2RXH2 2/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
AOC3 Q16853 4/20 0.52
EPHX1 P07099 2/20 0.52
ACP3 P15309 1/20 0.52
SLC6A2 P23975 1/20 0.50
SLC6A4 P31645 1/20 0.50
SLC6A3 Q01959 1/20 0.50
CYP1A2 P05177 1/20 0.50
TRPA1 O75762 1/20 0.48
RIPK1 Q13546 1/20 0.48
SMO Q99835 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125923 1.00 LMNA (0.58) LMNAKDM4EL3MBTL1AOC3EPHX1
SCHEMBL11552641 0.88 LMNA (0.52) LMNAKDM4EL3MBTL1AOC3EPHX1
SCHEMBL1838937 0.86 ESR1 (0.50) LMNAKDM4EL3MBTL1SLC6A2CYP1A2
SCHEMBL29152730 0.86 TAAR1 (0.54) KDM4E
SCHEMBL25343509 0.84 SMO (0.53) LMNAKDM4EL3MBTL1SLC6A2SLC6A4
SCHEMBL8145964 0.84 LMNA (0.48) LMNAKDM4EL3MBTL1AOC3EPHX1
SCHEMBL4058254 0.84 PPARG (0.49) LMNAKDM4EL3MBTL1AOC3SLC6A2
SCHEMBL8352649 0.84 SOAT1 (0.53) LMNAKDM4EL3MBTL1AOC3EPHX1
SCHEMBL12982418 0.84 MAOB (0.50) AOC3EPHX1SLC6A2SLC6A4SLC6A3
SCHEMBL13232184 0.84 TRPA1 (0.50) LMNAKDM4ESLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119613220-A Method for synthesizing chiral alcohol compound by hydrogenolysis and asymmetric synthesis of palladium-catalyzed epoxy compound 中国科学院大连化学物理研究所 2025-03-14 CN disclosed
CN-108250042-A (S)-(-) preparation method of -1,1,2- triphenyls -1,2- ethylene glycol 常州沃腾化工科技有限公司 2018-07-06 CN disclosed
EP-2511283-A1 N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2012-10-17 EP disclosed
WO-2010008729-A2 PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES AMGEN INC. (US) 2010-01-21 WO disclosed
US-20090275779-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE KANEKA CORPORATION (JP) 2009-11-05 US disclosed
EP-1942103-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE Kaneka Corporation (JP) 2008-07-09 EP disclosed
US-7241770-B2 Hydronopol derivatives as agonists on human ORL1 receptors SOLVAY PHARMACEUTICALS GMBH (DE) 2007-07-10 US disclosed
US-7109345-B1 Efficient and convenient procedure for the synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-09-19 US disclosed
US-20050131004-A1 Hydronopol derivatives as agonists on human ORL1 receptors SOLVAY PHARMACEUTICALS GMBH. 2005-06-16 US disclosed
US-5306844-A Tartaric acid amide derivative and method of producing the same MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1994-04-26 US disclosed
EP-0298695-B1 TARTARIC ACID AMIDE DERIVATIVE AND METHOD OF PRODUCING THE SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1993-05-12 EP disclosed
EP-0298695-A2 Tartaric acid amide derivative and method of producing the same MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131004-A1 Hydronopol derivatives as agonists on human ORL1 receptors OPRL1, ORMDL3, OGFRL1 LMNA 3711/4885KDM4E 4873/4885L3MBTL1 2414/4885
US-20090275779-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE SMS, SRM, ABHD5 LMNA 3742/4885KDM4E 1801/4885L3MBTL1 3935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.