SCHEMBL4356056

SCHEMBL4356056

COC(=O)CCc1cc(C(=O)c2cc(Cl)c(Cl)cc2C(=O)O)c(O)c(Cl)c1O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.33
KAT2B Q92831 3/20 0.33
MAPT P10636 2/20 0.32
ALDH1A1 P00352 2/20 0.32
HPGD P15428 2/20 0.32
HSD17B10 Q99714 2/20 0.32
POLB P06746 2/20 0.32
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
KDM4E B2RXH2 1/20 0.31
PKM P14618 1/20 0.31
HTT P42858 1/20 0.31
AKR1C4 P17516 1/20 0.31
AKR1C3 P42330 1/20 0.31
AKR1C2 P52895 1/20 0.31
AKR1C1 Q04828 1/20 0.31
TSHR P16473 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4422459 0.92 L3MBTL1 (0.37) L3MBTL1LMNAKAT2BMAPTALDH1A1
SCHEMBL4358116 0.88 L3MBTL1 (0.33) L3MBTL1LMNAKAT2BMAPTALDH1A1
SCHEMBL4011696 0.87 KMT2A (0.41) L3MBTL1LMNAALDH1A1POLBMEN1
SCHEMBL4014388 0.84 KDM4E (0.38) MAPTALDH1A1HPGDHSD17B10MEN1
SCHEMBL4013828 0.84 POLB (0.37) L3MBTL1LMNAKAT2BALDH1A1POLB
SCHEMBL4363671 0.83 DPP4 (0.37) L3MBTL1MAPTALDH1A1HSD17B10POLB
SCHEMBL4361731 0.83 L3MBTL1 (0.32) L3MBTL1KAT2BALDH1A1MEN1KMT2A
SCHEMBL2348285 0.83 PBRM1 (0.36) L3MBTL1POLBMEN1KMT2APKM
SCHEMBL10138023 0.83 TSHR (0.37) LMNAMAPTALDH1A1HPGDMEN1
SCHEMBL4359133 0.82 EGFR (0.36) L3MBTL1LMNAKAT2BMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8569516-B2 Compounds and methods for fluorescent labeling ELITECH HOLDING B.V. (NL) 2013-10-29 US disclosed
US-7601851-B2 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2009-10-13 US disclosed
EP-1466176-A4 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES INC (US) 2008-10-01 EP disclosed
US-7112684-B2 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2006-09-26 US disclosed
US-20060204990-A1 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2006-09-14 US disclosed
US-20050277144-A1 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2005-12-15 US disclosed
US-6972339-B2 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2005-12-06 US disclosed
US-20050176066-A1 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2005-08-11 US disclosed
US-20050171340-A1 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES, INC. (US) 2005-08-04 US disclosed
EP-1466176-A2 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING Epoch Biosciences, Inc. (US) 2004-10-13 EP disclosed
WO-2003023357-A2 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES, INC. (US) 2003-03-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050176066-A1 Compounds and methods for fluorescent labeling HLCS, GLB1, TUBB L3MBTL1 692/4885LMNA 221/4885KAT2B 687/4885
US-20060204990-A1 Compounds and methods for fluorescent labeling GLB1, HLCS, PFAS L3MBTL1 367/4885LMNA 257/4885KAT2B 632/4885
US-20050171340-A1 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING HLCS, GLB1, TUBB L3MBTL1 692/4885LMNA 221/4885KAT2B 687/4885
US-20050277144-A1 Compounds and methods for fluorescent labeling HLCS, GLB1, TUBB L3MBTL1 692/4885LMNA 221/4885KAT2B 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.