Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261486 | 0.91 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL19194749 | 0.90 | SLC6A2 (0.57) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL17086550 | 0.86 | BCL2A1 (0.49) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL21254366 | 0.86 | BCL2A1 (0.49) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL12120376 | 0.83 | FPR2 (0.48) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL11231139 | 0.81 | ADRB2 (0.46) | SLC6A4SLC6A2SLC6A3ADRB2HPGD | |
| SCHEMBL8380860 | 0.80 | FPR2 (0.41) | SLC6A4SLC6A2SLC6A3ADRB2FPR2 | |
| SCHEMBL19200332 | 0.77 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3CHRM1DRD3 | |
| SCHEMBL17602352 | 0.77 | POLB (0.42) | SLC6A4SLC6A2SLC6A3TSHR | |
| SCHEMBL23555214 | 0.77 | SLC6A2 (0.38) | SLC6A4SLC6A2SLC6A3FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206173-B2 | Heterocyclic compounds for the treatment of stress-related conditions | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-12-08 | — | — | US | disclosed |
| US-9206173-B2 | Heterocyclic compounds for the treatment of stress-related conditions | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-12-08 | — | — | US | disclosed |
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | NR3C1, NR3C2, CRH | SLC6A4 469/4885SLC6A2 281/4885SLC6A3 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.