Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573267 | 0.80 | ALDH1A1 (0.51) | ESR1ESR2KMT2AOPRK1POLB | |
| SCHEMBL14029004 | 0.80 | KMT2A (0.50) | ESR1ESR2KMT2AOPRK1POLB | |
| SCHEMBL15632250 | 0.80 | KMT2A (0.50) | KMT2AOPRK1POLBALDH1A1HPGD | |
| SCHEMBL31556360 | 0.77 | ALDH1A1 (0.41) | ESR1ESR2POLBALDH1A1LMNA | |
| SCHEMBL4659301 | 0.77 | KDM4E (0.44) | KMT2APOLBALDH1A1HSD17B10LMNA | |
| SCHEMBL11001297 | 0.77 | LMNA (0.46) | POLBALDH1A1LMNAMAPTTP53 | |
| SCHEMBL15549942 | 0.77 | KMT2A (0.47) | ESR1ESR2KMT2AOPRK1POLB | |
| SCHEMBL2884751 | 0.77 | ALDH1A1 (0.41) | ESR1ESR2POLBALDH1A1LMNA | |
| SCHEMBL16914973 | 0.77 | ALDH1A1 (0.45) | KMT2APOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL12130369 | 0.77 | ALDH1A1 (0.38) | ESR1ESR2KMT2AOPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| CN-101239953-A | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2008-08-13 | — | — | CN | disclosed |
| CN-101230066-A | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | WYETH CORP (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-101143867-A | Antidepressant indolealkyl derivatves of heterocyclefused benzodioxan methylamines | WYETH CORP (US) | 2008-03-19 | — | — | CN | disclosed |
| US-7335666-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-02-26 | — | — | US | disclosed |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-08 | — | — | US | disclosed |
| CN-1509290-A | Process for synthesis of derivatives of 2,30dihydro-1,4-dioxino-[2,3-f]quinoline | — | 2004-06-30 | — | — | CN | disclosed |
| WO-2004024733-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024731-A1 | ANTIDEPRESSANT ARYLPIPERAZINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024734-A1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024730-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| US-6693197-B2 | Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- [2,3-f] quinoline | WYETH | 2004-02-17 | — | — | US | disclosed |
| EP-1387845-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE | Wyeth (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | WYETH | 2002-12-12 | — | — | US | disclosed |
| WO-2002092602-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-[2,3-f] QUINOLINE | WYETH (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | CYP1A1, CYP2F1, CYP1B1 | ESR1 1976/4885ESR2 836/4885KMT2A 1775/4885 |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CYP19A1, CRH, CYP17A1 | ESR1 306/4885ESR2 639/4885KMT2A 3722/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | ESR1 403/4885ESR2 630/4885KMT2A 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.