Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.49 |
| ▸ | MAOA | P21397 | 7/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1277499 | 0.82 | TRPV4 (0.50) | AR | |
| SCHEMBL1869777 | 0.82 | PLA2G7 (0.39) | AR | |
| SCHEMBL6110658 | 0.82 | AR (0.43) | MAOBALDH1A1ARKDM4EUSP2 | |
| SCHEMBL29390509 | 0.79 | CYP19A1 (0.65) | MAOBMAOACYP19A1ALDH1A1HPGD | |
| SCHEMBL4581525 | 0.79 | CYP19A1 (0.65) | MAOBMAOACYP19A1ALDH1A1HPGD | |
| SCHEMBL1668579 | 0.79 | AR (0.61) | ALDH1A1ARKDM4EUSP2 | |
| SCHEMBL2017293 | 0.79 | XDH (0.49) | — | |
| SCHEMBL9472016 | 0.77 | CYP19A1 (0.62) | MAOBMAOACYP19A1ALDH1A1HPGD | |
| SCHEMBL1377229 | 0.77 | CYP19A1 (0.62) | MAOBMAOACYP19A1ALDH1A1HPGD | |
| SCHEMBL9560109 | 0.76 | MAOB (0.57) | MAOBMAOACYP19A1ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2072509-A1 | 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-24 | — | — | EP | disclosed |