Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549899 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL16695703 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL26768225 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL29853502 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL9225121 | 0.81 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2CDK4 | |
| SCHEMBL31498186 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL5196745 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL1120906 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL394584 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 | |
| SCHEMBL30634405 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1RXFP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206173-B2 | Heterocyclic compounds for the treatment of stress-related conditions | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-12-08 | — | — | US | disclosed |
| US-9206173-B2 | Heterocyclic compounds for the treatment of stress-related conditions | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-12-08 | — | — | US | disclosed |
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | NR3C1, NR3C2, CRH | KDM4E 3857/4885ALDH1A1 461/4885RXFP1 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.