E626

E626

SCHEMBL4361871

Nc1nc(=O)c2ncn(C3OC(COP(=O)(O)O)C(O)C3O)c2[nH]1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 4/20 0.61
TAS1R1 Q7RTX1 4/20 0.61
FBP1 P09467 2/20 0.61
DNPH1 O43598 1/20 0.61
PRKAB2 O43741 1/20 0.61
TRPM2 O94759 1/20 0.61
LDHA P00338 1/20 0.61
ADRB2 P07550 1/20 0.61
SRC P12931 1/20 0.61
ADORA1 P30542 1/20 0.61
P2RY2 P41231 1/20 0.61
P2RY1 P47900 1/20 0.61
PRKAG1 P54619 1/20 0.61
PRKAA2 P54646 1/20 0.61
PDE4D Q08499 1/20 0.61
KCNH2 Q12809 1/20 0.61
PRKAA1 Q13131 1/20 0.61
PDE3A Q14432 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
P2RY11 Q96G91 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E626 SCHEMBL94794 1.00 TAS1R3 (0.61) TAS1R3TAS1R1FBP1DNPH1PRKAB2
E626 SCHEMBL4360700 1.00 TAS1R3 (0.61) TAS1R3TAS1R1FBP1DNPH1PRKAB2
SCHEMBL4366717 0.93 TGM2 (0.62) SRCP2RY2P2RY1SMN1; SMN2P2RY11
SCHEMBL4366674 0.93 TGM2 (0.62) SRCP2RY2P2RY1SMN1; SMN2P2RY11
SCHEMBL37406 0.93 TGM2 (0.62) SRCP2RY2P2RY1SMN1; SMN2P2RY11
SCHEMBL4362564 0.92 TGM2 (0.65) TRPM2SRCP2RY2P2RY1SMN1; SMN2
SCHEMBL4357900 0.92 TGM2 (0.65) TRPM2SRCP2RY2P2RY1SMN1; SMN2
SCHEMBL18661219 0.92 TGM2 (0.65) TRPM2SRCP2RY2P2RY1SMN1; SMN2
E626 SCHEMBL20266271 0.91 NT5E (0.57) TAS1R3TAS1R1FBP1DNPH1PRKAB2
Gtp SCHEMBL4362801 0.91 TGM2 (0.62) SRCP2RY2P2RY1SMN1; SMN2P2RY11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150366777-A1 COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION HYPERMARCAS S.A. (BR) 2015-12-24 US claimed
CN-114903028-B Erythrocyte cryoprotectant and preparation method and application thereof 华南理工大学 2023-10-17 CN disclosed
CN-114903028-A Erythrocyte cryoprotectant and preparation method and application thereof 华南理工大学 2022-08-16 CN disclosed
CN-106999973-A System and method for discharging edible material 阿甘芳香和精细化工有限公司 2017-08-01 CN disclosed
US-20150366777-A1 COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION HYPERMARCAS S.A. (BR) 2015-12-24 US disclosed
US-20090186358-A1 Pathway Analysis of Cell Culture Phenotypes and Uses Thereof WYETH (US) 2009-07-23 US disclosed