Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of E626. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 known ✓ | P47900 | 6/20 | 0.54 |
| ▸ | ADORA1 known ✓ | P30542 | 3/20 | 0.52 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.52 |
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.51 |
| ▸ | IMPDH2 known ✓ | P12268 | 4/20 | 0.50 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.50 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.50 |
| ▸ | IMPDH1 known ✓ | P20839 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E626 SCHEMBL4361871 | 0.91 | TAS1R3 (0.61) | NT5EP2RY1TGM2ADORA1P2RY11 | |
| E626 SCHEMBL4360700 | 0.91 | TAS1R3 (0.61) | NT5EP2RY1TGM2ADORA1P2RY11 | |
| E626 SCHEMBL94794 | 0.91 | TAS1R3 (0.61) | NT5EP2RY1TGM2ADORA1P2RY11 | |
| SCHEMBL20266252 | 0.91 | TGM2 (0.62) | NT5EP2RY1ENPP1TGM2P2RY12 | |
| SCHEMBL4362564 | 0.89 | TGM2 (0.65) | NT5EP2RY1ENPP1TGM2P2RY11 | |
| SCHEMBL4357900 | 0.89 | TGM2 (0.65) | NT5EP2RY1ENPP1TGM2P2RY11 | |
| SCHEMBL18661219 | 0.89 | TGM2 (0.65) | NT5EP2RY1ENPP1TGM2P2RY11 | |
| SCHEMBL37406 | 0.88 | TGM2 (0.62) | NT5EP2RY1ENPP1TGM2P2RY11 | |
| SCHEMBL4366717 | 0.88 | TGM2 (0.62) | NT5EP2RY1ENPP1TGM2P2RY11 | |
| SCHEMBL4366674 | 0.88 | TGM2 (0.62) | NT5EP2RY1ENPP1TGM2P2RY11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250381110-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | PROCTER & GAMBLE (US) | 2025-12-18 | — | — | US | disclosed |
| US-20250288624-A1 | LONG-TERM STABILIZATION, FORMULATION AND TABLETING OF LIVE MICROBIAL CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-09-18 | — | — | US | disclosed |
| CN-118562917-B | Method for biosynthesis of guanosine diphosphate by multienzyme method | 汇海(苏州)生物技术有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-119086766-A | Method for simultaneously testing 5 nucleotides and 5 nucleosides | 深圳市计量质量检测研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-118562917-A | Method for biosynthesis of guanosine diphosphate by multienzyme method | 汇海(苏州)生物技术有限公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-4403042-A2 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | Mars, Incorporated (US) | 2024-07-24 | — | — | EP | disclosed |
| EP-3229612-B1 | USE OF FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | MARS INC (US) | 2024-06-26 | — | — | EP | disclosed |
| CN-115856173-A | Detection method of central carbon and amino acid and application thereof | 北京诺禾致源科技股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-11612575-B2 | Combination therapies with disulfiram | Spring Discovery, Inc. (US) | 2023-03-28 | — | — | US | disclosed |
| US-20220087956-A1 | COMBINATION THERAPIES WITH DISULFIRAM | WINTER ACQUISITION SUB, INC. | 2022-03-24 | — | — | US | disclosed |
| US-11033516-B1 | Combination therapies with disulfiram | Spring Discovery, Inc. (US) | 2021-06-15 | — | — | US | disclosed |
| EP-3229610-B1 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | MARS INC (US) | 2021-06-09 | — | — | EP | disclosed |
| CN-111743127-A | Stewed chicken juice and preparation method thereof | 广州味滋美食品有限公司 | 2020-10-09 | — | — | CN | disclosed |
| US-20190021380-A1 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | MARS, INCORPORATED (US) | 2019-01-24 | — | — | US | disclosed |
| CN-109090570-A | Delicate flavor pepper sauce, preparation method and its application in nutrition pungent snack food | 湖南狄师傅食品科技有限公司 | 2018-12-28 | — | — | CN | disclosed |
| US-20180255813-A1 | METHODS FOR MODULATING TASTE RECEPTORS | MARS, INCORPORATED (US) | 2018-09-13 | — | — | US | disclosed |
| US-20180168208-A1 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | MARS, INCORPORATED (US) | 2018-06-21 | — | — | US | disclosed |
| CN-106999973-A | System and method for discharging edible material | 阿甘芳香和精细化工有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-105146597-A | Sesame seed sandwich nori and preparation method thereof | JINJIANG LILV FOOD CO LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-104974863-A | Cleaning agent for glass curtain wall and preparation method thereof | Shandong xiangshan decoration engineering co ltd | 2015-10-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250381110-A1 | SKIN CARE COMPOSITION AND METHOD OF USING THE SAME | SQSTM1, BECN1, CUTA | P2RY1 1077/4885ADORA1 1414/4885ADORA3 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.