Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSB | P07858 | 3/20 | 0.64 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.62 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.55 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659468 | 0.84 | TYR (0.77) | CTSLCTSBCHRNA7TYRCAPN1 | |
| SCHEMBL1659465 | 0.84 | TYR (0.77) | CTSLCTSBCHRNA7TYRCAPN1 | |
| SCHEMBL4953076 | 0.84 | CHRNA7 (0.61) | CHRNA7TYRRELAALDH1A1MAPT | |
| SCHEMBL9819136 | 0.83 | AR (0.64) | CTSLCTSBTNFRSF1ATYRCAPN1 | |
| SCHEMBL9819142 | 0.83 | AR (0.64) | CTSLCTSBTNFRSF1ATYRCAPN1 | |
| SCHEMBL29837087 | 0.83 | AR (0.64) | CTSLCTSBTNFRSF1ATYRCAPN1 | |
| SCHEMBL14759265 | 0.81 | CHRNA7 (0.48) | CTSLCTSBCHRNA7TYRCAPN1 | |
| SCHEMBL29023640 | 0.81 | MAPT (0.71) | CHRNA7TNFRSF1ATYRMAPTMEN1 | |
| SCHEMBL9337650 | 0.81 | ALDH1A1 (0.65) | CHRNA7CAPN1GABRA3GABRA2GABRB2 | |
| SCHEMBL10384464 | 0.81 | GABRA3 (0.84) | CTSLCTSBTNFRSF1ACAPN1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482340-B2 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2009-01-27 | — | — | US | disclosed |
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2006-10-26 | — | — | US | disclosed |
| EP-1583759-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063191-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | SLC8B1, CACNA1A, MCU | CTSL 3740/4885CTSB 2898/4885CHRNA7 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.