Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437855 | 0.82 | F2 (0.43) | S1PR1LMNATP53F2F10 | |
| SCHEMBL5225410 | 0.77 | CA12 (0.47) | S1PR1F2F10CA12CA2 | |
| SCHEMBL433953 | 0.74 | STS (0.43) | S1PR1LMNATP53F2F10 | |
| SCHEMBL18067895 | 0.74 | S1PR1 (0.44) | S1PR1F2F10TLR8CYP2C8 | |
| SCHEMBL3244824 | 0.72 | TBXAS1 (0.51) | TP53F2F10ALOX15 | |
| SCHEMBL12117962 | 0.72 | MAPT (0.46) | LMNATP53F2F10KDM4E | |
| SCHEMBL12038075 | 0.72 | F2 (0.44) | S1PR1LMNATP53F2F10 | |
| SCHEMBL5673192 | 0.72 | F2 (0.47) | TP53F2F10KDM4ECA12 | |
| SCHEMBL284155 | 0.71 | TLR8 (0.50) | F2F10CA2ALOX15TLR8 | |
| SCHEMBL2330441 | 0.71 | ALOX15 (0.58) | LMNAF2F10KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816103-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2014-08-26 | — | — | US | disclosed |
| EP-2595978-A1 | NOVEL PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2013-05-29 | — | — | EP | disclosed |
| US-20130131358-A1 | Novel Process for the Preparation of Dronedarone | SANOFI (FR) | 2013-05-23 | — | — | US | disclosed |
| WO-2012010913-A1 | NOVEL PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131358-A1 | Novel Process for the Preparation of Dronedarone | CYP2F1, CYP3A4, CYP2D6 | S1PR1 3666/4885LMNA 473/4885TP53 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.