Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 known ✓ | P39086 | 1/20 | 0.39 |
| ▸ | GRIA1 known ✓ | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 known ✓ | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 known ✓ | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 known ✓ | P48058 | 1/20 | 0.39 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.39 |
| ▸ | GRIK2 known ✓ | Q13002 | 1/20 | 0.39 |
| ▸ | GRIK3 known ✓ | Q13003 | 1/20 | 0.39 |
| ▸ | GRIK5 known ✓ | Q16478 | 1/20 | 0.39 |
| ▸ | HDAC3 known ✓ | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 known ✓ | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 known ✓ | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL2826637 | 1.00 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL2826645 | 1.00 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL10427322 | 1.00 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL4364490 | 1.00 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL161676 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL161673 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL2589315 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL5604901 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL5604919 | 0.98 | CA1 (0.48) | CA1BBOX1GRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL3882457 | 0.95 | CA1 (0.46) | CA1BBOX1GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744770-A2 | HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS | Osteologix A/S (DK) | 2007-01-24 | — | — | EP | claimed |
| WO-2005108339-A2 | HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS | OSTEOLOGIX A/S (DK) | 2005-11-17 | — | — | WO | claimed |
| US-8183409-B2 | High yield and rapid synthesis methods for producing metallo-organic salts | OSTEOLOGIX A/S (DK) | 2012-05-22 | — | — | US | disclosed |
| US-20090291926-A1 | HIGH YIELD AND RAPID SYNTHESIS METHODS FOR PRODUCING METALLO-ORGANIC SALTS | CHRISTGAU STEPHAN | 2009-11-26 | — | — | US | disclosed |
| US-7589235-B2 | High yield and rapid synthesis methods for producing metallo-organic salts | OSTEOLOGIX, A/S (DK) | 2009-09-15 | — | — | US | disclosed |
| US-20070282127-A1 | High Yield And Rapid Synthesis Methods For Producing Metallo-Organic Salts | OSTEOLOGIX A/S | 2007-12-06 | — | — | US | disclosed |
| EP-1744770-A2 | HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS | Osteologix A/S (DK) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108339-A2 | HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS | OSTEOLOGIX A/S (DK) | 2005-11-17 | — | — | WO | disclosed |