SCHEMBL4364012

SCHEMBL4364012

N[C@H](CCc1ccccc1)C(=O)NOCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
METAP2 P50579 1/20 0.50
METAP1 P53582 1/20 0.50
LNPEP Q9UIQ6 5/20 0.49
ERAP2 Q6P179 3/20 0.49
LTA4H P09960 3/20 0.47
TSHR P16473 1/20 0.46
ALPI P09923 1/20 0.46
PKM P14618 1/20 0.46
PTGS1 P23219 1/20 0.46
XIAP P98170 1/20 0.46
SLC7A5 Q01650 1/20 0.46
CTSC P53634 1/20 0.46
ERAP1 Q9NZ08 3/20 0.45
ANPEP P15144 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18661138 1.00 NPC1 (0.53) NPC1RAB9AMETAP2METAP1LNPEP
SCHEMBL21364100 0.89 LNPEP (0.45) NPC1RAB9AMETAP2METAP1LNPEP
SCHEMBL21122445 0.85 ALPI (0.59) NPC1RAB9ALNPEPLTA4HALPI
SCHEMBL17887278 0.85 ALDH1A1 (0.44) NPC1LNPEPERAP2CTSC
SCHEMBL6476935 0.85 METAP2 (0.70) NPC1RAB9AMETAP2METAP1LTA4H
Hydrochloric Acid SCHEMBL20516398 0.84 ALPI (0.58) NPC1RAB9ALNPEPLTA4HALPI
Hydrochloric Acid SCHEMBL5961098 0.84 ALPI (0.58) NPC1RAB9ALNPEPLTA4HALPI
SCHEMBL4364135 0.83 LNPEP (0.60) METAP2METAP1LNPEPERAP2TSHR
SCHEMBL18661110 0.83 LNPEP (0.60) METAP2METAP1LNPEPERAP2TSHR
SCHEMBL16898303 0.82 NPC1 (0.50) NPC1RAB9AMETAP2METAP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451776-B1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING INC (US) 2019-09-18 EP disclosed
EP-2451776-B1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING INC (US) 2019-09-18 EP disclosed
CN-103965128-B N alkoxy amide conjugates as developer 兰休斯医疗成像公司 2018-04-03 CN disclosed
US-9732047-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2017-08-15 US disclosed
US-9732047-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2017-08-15 US disclosed
EP-2240206-B1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING INC (US) 2017-03-22 EP disclosed
EP-2240206-B1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING INC (US) 2017-03-22 EP disclosed
US-20170029386-A9 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2017-02-02 US disclosed
US-20170029386-A9 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2017-02-02 US disclosed
US-9393329-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2016-07-19 US disclosed
US-20150094465-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2015-04-02 US disclosed
US-20150078997-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2015-03-19 US disclosed
US-8877157-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2014-11-04 US disclosed
US-8852553-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2014-10-07 US disclosed
US-20130315822-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2013-11-28 US disclosed
US-8361438-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2013-01-29 US disclosed
US-8361438-B2 N-alkoxyamide conjugates as imaging agents LANTHEUS MEDICAL IMAGING, INC. (US) 2013-01-29 US disclosed
US-20120328514-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC. (US) 2012-12-27 US disclosed
US-20090252676-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC (US) 2009-10-08 US disclosed
US-20090252676-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS LANTHEUS MEDICAL IMAGING, INC (US) 2009-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150094465-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885
US-20170029386-A9 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885
US-20130315822-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885
US-20120328514-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885
US-20150078997-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885
US-20090252676-A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS TNNT2, UACA, ELANE NPC1 3747/4885RAB9A 3216/4885METAP2 2330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.