Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | METAP2 | P50579 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963509 | 0.79 | PSMD14 (0.45) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL318769 | 0.77 | NR4A2 (0.68) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL29410781 | 0.77 | NR4A2 (0.68) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL13201607 | 0.76 | SLC40A1 (0.47) | MEN1KMT2AHSP90AA1HTR1APSMD14 | |
| SCHEMBL13409385 | 0.76 | PSMD14 (0.40) | TDP1LMNAHSP90AA1NR4A2CYP3A4 | |
| SCHEMBL317120 | 0.76 | HTR1A (0.56) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL18539683 | 0.73 | PSMD14 (0.77) | KDM4ELMNANR4A2PSMD14L3MBTL1 | |
| SCHEMBL22288159 | 0.73 | HSP90AA1 (0.48) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL29661831 | 0.73 | HSP90AA1 (0.48) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL27051239 | 0.72 | CYP1A2 (0.59) | KDM4EALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2072502-A1 | Sulfoximide substituted chinolin and chinazolin derivatives as kinase inhibitors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-24 | — | — | EP | disclosed |