Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2892111 | 0.78 | HTT (0.56) | KMT2AMEN1HSPD1HSPE1CYP11B2 | |
| SCHEMBL31450301 | 0.75 | HCAR2 (0.39) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL3720517 | 0.75 | HCAR2 (0.39) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9197573 | 0.74 | ROCK2 (0.79) | KMT2AMEN1SMOCYP11B2JAK2 | |
| SCHEMBL766990 | 0.74 | HSPD1 (0.57) | KMT2AMEN1HSPD1HSPE1ALDH1A1 | |
| SCHEMBL31582632 | 0.73 | MAOB (0.35) | ROCK2ROCK1POLB | |
| SCHEMBL882734 | 0.73 | KMT2A (0.80) | KMT2AMEN1HSPD1HSPE1ALDH1A1 | |
| SCHEMBL3788790 | 0.73 | ALDH1A1 (0.66) | KMT2AMEN1SMOJAK2ALDH1A1 | |
| SCHEMBL8269199 | 0.72 | TYK2 (0.60) | SMOCYP11B2JAK2TYK2ALDH1A1 | |
| SCHEMBL28072777 | 0.72 | JAK2 (0.67) | KMT2AMEN1SMOCYP11B2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125780-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | Amgen Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079294-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | AMGEN INC. (US) | 2008-07-03 | — | — | WO | disclosed |