Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249890 | 0.96 | MMP12 (0.48) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2242485 | 0.91 | MMP2 (0.45) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2248769 | 0.90 | MMP12 (0.44) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2254232 | 0.89 | MMP12 (0.47) | MMP12MMP2MMP8ADAMTS5MME | |
| SCHEMBL2247913 | 0.88 | MMP2 (0.39) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2251633 | 0.88 | MMP2 (0.41) | MMP12MMP2MMP8ADAMTS5FOLH1 | |
| SCHEMBL2247591 | 0.88 | MMP12 (0.42) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2248055 | 0.87 | MMP2 (0.42) | MMP12MMP2MMP8ADAMTS5MCHR1 | |
| SCHEMBL2247681 | 0.86 | MMP12 (0.45) | MMP12MMP2MMP8ADAMTS5MME | |
| SCHEMBL2247710 | 0.86 | ADAMTS5 (0.38) | MMP12MMP2MMP8ADAMTS5MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | MMP12 54/4885MMP2 49/4885MMP8 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.