Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986333 | 0.86 | MEN1 (0.48) | KMT2AMEN1POLBGRM5NPC1 | |
| SCHEMBL4367794 | 0.84 | GRM5 (0.45) | KMT2AMEN1GRM5NPC1NPSR1 | |
| SCHEMBL4366803 | 0.83 | NPC1 (0.36) | KMT2ANPC1ALOX15TSHRCASP1 | |
| SCHEMBL6983249 | 0.82 | KMT2A (0.44) | KMT2AMEN1POLBGRM5NPC1 | |
| SCHEMBL6987283 | 0.79 | KMT2A (0.44) | KMT2AMEN1POLBGRM5ALOX15 | |
| SCHEMBL6990458 | 0.78 | CSF1R (0.44) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL6981925 | 0.75 | NAMPT (0.50) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL6987131 | 0.75 | GRM5 (0.44) | KMT2AMEN1GRM5NPC1TSHR | |
| SCHEMBL6988714 | 0.75 | SIRT2 (0.43) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL6981005 | 0.74 | POLB (0.42) | KMT2AMEN1POLBNPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |