Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330588 | 0.84 | ACLY (0.74) | KCNMA1KDM4EALDH1A1HIF1AMETAP2 | |
| SCHEMBL13928800 | 0.83 | KCNMA1 (0.72) | KCNMA1KDM4EALDH1A1HIF1AMETAP2 | |
| SCHEMBL30692667 | 0.81 | TMPRSS4 (0.76) | KCNMA1STK39P2RX1TMPRSS4 | |
| SCHEMBL24438295 | 0.81 | TMPRSS4 (0.76) | KCNMA1STK39P2RX1TMPRSS4 | |
| SCHEMBL30081452 | 0.80 | KMT2A (0.74) | KCNMA1KDM4EALDH1A1HIF1APPARG | |
| SCHEMBL30692657 | 0.80 | ALDH1A1 (0.70) | KCNMA1KDM4EALDH1A1STK39LMNA | |
| SCHEMBL24438157 | 0.80 | ALDH1A1 (0.70) | KCNMA1KDM4EALDH1A1STK39LMNA | |
| SCHEMBL1025899 | 0.80 | KMT2A (0.74) | KCNMA1KDM4EALDH1A1HIF1APPARG | |
| SCHEMBL29528138 | 0.80 | KMT2A (0.74) | KCNMA1KDM4EALDH1A1HIF1APPARG | |
| SCHEMBL13812698 | 0.79 | KCNMA1 (0.51) | KCNMA1KDM4EHIF1APPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20050187300-A1 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INCORPORATED (US) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187300-A1 | Compounds, compositions, and methods employing same | HMGCR, APOB, PCSK9 | KCNMA1 3818/4885KDM4E 4397/4885ALDH1A1 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.