SCHEMBL4367409

SCHEMBL4367409

COC(=O)[C@H](N)Cc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.62
MMP2 P08253 2/20 0.50
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
LMNA P02545 1/20 0.48
DPP4 P27487 2/20 0.46
DPP7 Q9UHL4 2/20 0.46
DPP8 Q6V1X1 1/20 0.46
DPP9 Q86TI2 1/20 0.46
IDO1 P14902 2/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
NPC1 O15118 2/20 0.46
TP53 P04637 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAOB P27338 1/20 0.46
MC4R P32245 1/20 0.46
GAA P10253 1/20 0.45
MAPK1 P28482 1/20 0.45
FAP Q12884 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3317059 1.00 ALDH1A1 (0.62) ALDH1A1MMP2MEN1KMT2ALMNA
SCHEMBL240405 1.00 ALDH1A1 (0.62) ALDH1A1MMP2MEN1KMT2ALMNA
Hydrochloric Acid SCHEMBL4371678 0.98 ALDH1A1 (0.64) ALDH1A1MMP2MEN1KMT2ALMNA
Hydrochloric Acid SCHEMBL1230535 0.98 ALDH1A1 (0.64) ALDH1A1MMP2MEN1KMT2ALMNA
Hydrochloric Acid SCHEMBL240404 0.98 ALDH1A1 (0.64) ALDH1A1MMP2MEN1KMT2ALMNA
SCHEMBL27546222 0.98 ALDH1A1 (0.61) ALDH1A1MMP2MEN1KMT2ALMNA
SCHEMBL8211198 0.93 ALDH1A1 (0.56) ALDH1A1MMP2MEN1KMT2ADPP4
SCHEMBL4097192 0.93 ALDH1A1 (0.56) ALDH1A1MMP2MEN1KMT2ADPP4
SCHEMBL11651148 0.88 MMP2 (0.49) ALDH1A1MMP2LMNADPP4DPP7
SCHEMBL1859542 0.87 MAPT (0.50) ALDH1A1MMP2LMNADPP4DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2025-12-02 US disclosed
WO-2024097355-A1 DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS VICINITAS THERAPEUTICS, INC. (US) 2024-05-10 WO disclosed
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2022-04-14 US disclosed
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2022-04-14 US disclosed
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2022-03-22 US disclosed
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2022-03-22 US disclosed
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2019-02-07 US disclosed
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2019-02-07 US disclosed
CN-109104863-A Somatostatin receptor antagonist compound and its application method 克德瑞德风险投资公司 2018-12-28 CN disclosed
EP-3414259-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD Ventures Inc. (CA) 2018-12-19 EP disclosed
WO-2007028639-A1 METHOD FOR THE SYNTHESIS OF PENTAPENDANT ENANTIOMER-PURE CHELATORS AND PROCESS FOR THERAPEUTICALLY ACTIVE BIO-CONJUGATES PREPARATION BY A COVALENT BINDING OF THEREOF THERAPHARM GMBH (CH) 2007-03-15 WO disclosed
US-6235876-B1 Liquid phase process for the preparation of GNRH peptides ORTHO-MCNEIL PHARMACEUTICAL, INC. 2001-05-22 US disclosed
US-5977075-A N-aroylamino acid amides as endothelin inhibitors NOVARTIS AG (CH) 1999-11-02 US disclosed
US-5977302-A SOLUTION PHASE SYNTHESIS PERMITTING LARGE SCALE BULK PRODUCTION USING A MINIMUM NUMBER OF STEPS; REDUCED UNWANTED SIDE REACTIONS AND ELIMINATION OF SIDE CHAIN PROTECTION STEPS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 1999-11-02 US disclosed
WO-1999026964-A1 LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 1999-06-03 WO disclosed
US-5780498-A PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS CIBA-GEIGY JAPAN LIMITED (JP) 1998-07-14 US disclosed
EP-0821670-A1 N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS Novartis AG (CH) 1998-02-04 EP disclosed
WO-1996033170-A1 N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS NOVARITS AG (CH) 1996-10-24 WO disclosed
EP-0728145-A1 ENDOTHELIN RECEPTOR ANTAGONISTS Ciba-Geigy Japan Limited (JP) 1996-08-28 EP disclosed
WO-1995012611-A1 ENDOTHELIN RECEPTOR ANTAGONISTS JAPAT LTD. (CH) 1995-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 ALDH1A1 4110/4885MMP2 3213/4885MEN1 203/4885
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 ALDH1A1 4077/4885MMP2 3203/4885MEN1 205/4885
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 ALDH1A1 4110/4885MMP2 3213/4885MEN1 203/4885
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 ALDH1A1 4077/4885MMP2 3203/4885MEN1 205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.