Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 3/20 | 0.34 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346598 | 0.83 | KHK (0.40) | SMN1; SMN2TP53 | |
| SCHEMBL345716 | 0.79 | KHK (0.40) | — | |
| SCHEMBL436765 | 0.78 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL435693 | 0.78 | SSTR4 (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL346082 | 0.75 | MMP3 (0.40) | — | |
| SCHEMBL346576 | 0.74 | GRIN2B (0.44) | — | |
| SCHEMBL435694 | 0.74 | GHSR (0.35) | OPRD1OPRK1OPRM1 | |
| SCHEMBL436428 | 0.74 | RAF1 (0.32) | — | |
| SCHEMBL434259 | 0.73 | F10 (0.39) | — | |
| SCHEMBL346261 | 0.73 | BRAF (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012320-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENIUM PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |