Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 13/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 5/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | MMP14 | P50281 | 4/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.46 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800964 | 0.93 | ADAM17 (0.47) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1801225 | 0.92 | BMP1 (0.51) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1800811 | 0.86 | BMP1 (0.51) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1800828 | 0.85 | BMP1 (0.51) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1800002 | 0.84 | ADAM17 (0.45) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL4381231 | 0.84 | BMP1 (0.43) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1799495 | 0.84 | ADAM17 (0.47) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL1798434 | 0.80 | ADAM17 (0.43) | BMP1MMP1MMP2MMP9MMP14 | |
| SCHEMBL3872450 | 0.78 | MMP13 (0.56) | BMP1MMP13MMP1MMP2MMP9 | |
| SCHEMBL4371607 | 0.78 | MMP2 (0.44) | BMP1MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |