Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 5/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801225 | 0.85 | BMP1 (0.51) | BMP1MMP13MMP2MMP9ADAM17 | |
| SCHEMBL3878927 | 0.85 | MMP13 (0.53) | BMP1MMP13MMP2TACR2MMP9 | |
| SCHEMBL3875831 | 0.84 | MMP13 (0.54) | BMP1MMP13MMP2TACR2MMP9 | |
| SCHEMBL4369618 | 0.84 | BMP1 (0.51) | BMP1MMP13MMP2MMP9ADAM17 | |
| SCHEMBL1800811 | 0.83 | BMP1 (0.51) | BMP1MMP13MMP2MMP9ADAM17 | |
| SCHEMBL1800828 | 0.81 | BMP1 (0.51) | BMP1MMP13MMP2MMP9ADAM17 | |
| SCHEMBL4370883 | 0.81 | WNT3A (0.37) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL1799823 | 0.81 | ADAM17 (0.42) | BMP1MMP13MMP2MMP9ADAM17 | |
| SCHEMBL4369114 | 0.80 | MMP2 (0.40) | MMP13MMP2TACR2MMP9MMP1 | |
| SCHEMBL1799495 | 0.79 | ADAM17 (0.47) | BMP1MMP13MMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |