Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10465961 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL4369897 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL10824215 | 0.94 | LMNA (0.62) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28090059 | 0.91 | TSHR (0.53) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL11169845 | 0.86 | TSHR (0.58) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL29253200 | 0.84 | — | — | |
| Adamantane SCHEMBL4451200 | 0.84 | THRB (0.50) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL23036094 | 0.81 | TSHR (0.69) | TSHRTP53EGLN1EGLN3LMNA | |
| Acrylic Acid SCHEMBL2212958 | 0.81 | LMNA (0.77) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL6686451 | 0.81 | LMNA (0.77) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4041014-A | N-OCTYL TIN ISOOCTYL MERCAPTOACETATES AND A DI-N-OCTYL TIN MALEATE OLIGOMER AS DISCOLORATION INHIBITORS | M&T CHEMICALS INC. (US) | 1977-08-09 | — | — | US | claimed |
| JP-1292621-A | — | — | None | — | — | JP | disclosed |
| JP-9180549-A | — | — | None | — | — | JP | disclosed |
| CN-110997798-B | Fiber reinforced polyvinyl chloride and copolyester compositions and articles made using these compositions | 伊士曼化工公司 | 2024-04-05 | — | — | CN | disclosed |
| EP-3894472-B1 | POLYVINYL CHLORIDE, POLYCARBONATE AND COPOLYESTER COMPOSITIONS AND ARTICLES MADE USING THESE COMPOSITIONS | EASTMAN CHEM CO (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3642278-B1 | POLYVINYL CHLORIDE AND COPOLYESTER COMPOSITIONS AND ARTICLES MADE USING THESE COMPOSITIONS | EASTMAN CHEM CO (US) | 2023-10-18 | — | — | EP | disclosed |
| EP-3385072-B1 | ANTIFOULING COMPOSITE COATING FILM, ANTIFOULING SUBSTRATE, AND METHOD FOR MANUFACTURING ANTIFOULING SUBSTRATE | CHUGOKU MARINE PAINTS (JP) | 2023-09-06 | — | — | EP | disclosed |
| CN-113166511-B | Polyvinyl chloride, polycarbonate and copolyester compositions and articles made using these compositions | 伊士曼化工公司 | 2023-07-28 | — | — | CN | disclosed |
| EP-3385345-B1 | ANTIFOULING COATING COMPOSITION, ANTIFOULING COATING FILM, ANTIFOULING BASE, AND METHOD OF MANUFACTURING ANTIFOULING BASE | CHUGOKU MARINE PAINTS (JP) | 2023-05-31 | — | — | EP | disclosed |
| EP-4165130-A1 | POLYVINYL CHLORIDE, POLYCARBONATE AND COPOLYESTER COMPOSITIONS AND ARTICLES MADE USING THESE COMPOSITIONS | Eastman Chemical Company (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-0119011-A1 | Adhesive process | HERCULES INCORPORATED (US) | 1984-09-19 | — | — | EP | disclosed |
| US-4447495-A | AN AZIDOSILANE COUPLING AGENT FOR ADHEARING POLYMER AND SILICEOUS MATERIAL | HERCULES, INCORPORATED (US) | 1984-05-08 | — | — | US | disclosed |
| US-4397401-A | Easily openable vessel closure and process for preparation thereof | TOYO SEIKAN KAISHA LTD. (JP) | 1983-08-09 | — | — | US | disclosed |
| US-4352938-A | ADHESION OF POLYPROPYLENE TO GLASS FIBERS OR TIRE CORDS TO RUBBER | HERCULES INCORPORATED (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0059635-A2 | Easily openable vessel closure and process for preparation thereof | TOYO SEIKAN KAISHA LIMITED (JP) | 1982-09-08 | — | — | EP | disclosed |
| US-4277593-A | COUPLING AGENTS | HERCULES INCORPORATED (US) | 1981-07-07 | — | — | US | disclosed |
| US-4208315-A | ALSO USED FOR AUTOMOTIVE PARTS, WIRE AND CABLE COATINGS | SHELL OIL COMPANY (US) | 1980-06-17 | — | — | US | disclosed |
| US-4147690-A | MAGNESIUM HYDROXIDE, ALUMINA TRIHYDRATE | THE BURNS & RUSSELL COMPANY OF BALTIMORE (US) | 1979-04-03 | — | — | US | disclosed |
| US-4041014-A | N-OCTYL TIN ISOOCTYL MERCAPTOACETATES AND A DI-N-OCTYL TIN MALEATE OLIGOMER AS DISCOLORATION INHIBITORS | M&T CHEMICALS INC. (US) | 1977-08-09 | — | — | US | disclosed |
| US-3971743-A | CROSSLINKING POLYMERS | HERCULES INCORPORATED (US) | 1976-07-27 | — | — | US | disclosed |