Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366400 | 0.86 | CXCR2 (0.40) | MAPKAPK2ADAMTS5NR3C2CXCR2PDGFRA | |
| SCHEMBL4370003 | 0.83 | MAPKAPK2 (0.50) | MAPKAPK2ADAMTS5NR3C2CXCR2PDGFRA | |
| SCHEMBL8767825 | 0.74 | CXCR2 (0.44) | CXCR2MAPK1ALDH1A1 | |
| SCHEMBL4364985 | 0.74 | SMN1; SMN2 (0.38) | ADAMTS5NR3C2CXCR2MAPK1ALDH1A1 | |
| SCHEMBL8768875 | 0.72 | CXCR2 (0.43) | ADAMTS5NR3C2CXCR2 | |
| SCHEMBL4370740 | 0.70 | FLT4 (0.56) | MAPKAPK2CXCR2MAPK1AURKBCSNK1G1 | |
| SCHEMBL4371397 | 0.70 | MAPKAPK2 (0.72) | MAPKAPK2PDGFRAMAPK1AURKBCSNK1G1 | |
| SCHEMBL16102053 | 0.70 | MAPKAPK2 (0.72) | MAPKAPK2PDGFRAMAPK1AURKBCSNK1G1 | |
| SCHEMBL8769026 | 0.70 | ADAMTS5 (0.46) | ADAMTS5NR3C2CXCR2 | |
| SCHEMBL16100308 | 0.68 | POLB (0.42) | MAPKAPK2SMARCA2SMARCA4AURKBGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |