SCHEMBL8769026

SCHEMBL8769026

CCN(c1ccccc1)c1c(Nc2ccc(OC(F)(F)F)cc2)c(=O)c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 2/20 0.46
PLK1 P53350 2/20 0.45
HDAC1 Q13547 1/20 0.41
LMNA P02545 2/20 0.39
GAA P10253 1/20 0.39
HTT P42858 1/20 0.39
CNR2 P34972 1/20 0.38
NR3C2 P08235 1/20 0.38
POLB P06746 1/20 0.38
CXCR2 P25025 1/20 0.38
DHODH Q02127 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.36
MAPT P10636 2/20 0.36
EPHX2 P34913 2/20 0.36
PLA2G1B P04054 1/20 0.36
ATG4B Q9Y4P1 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4370003 0.78 MAPKAPK2 (0.50) ADAMTS5PLK1NR3C2CXCR2
SCHEMBL8768875 0.77 CXCR2 (0.43) ADAMTS5NR3C2CXCR2MAPT
SCHEMBL8768956 0.71 ADAMTS5 (0.46) ADAMTS5HDAC1LMNAGAAPOLB
SCHEMBL8870928 0.71 POLB (0.60) ADAMTS5PLK1HDAC1LMNAGAA
SCHEMBL8870080 0.71 MAPKAPK2 (0.62) PLK1HDAC1
SCHEMBL9149213 0.71 MAPKAPK2 (0.62) PLK1HDAC1
SCHEMBL8769034 0.70 FES (0.59) PLK1HDAC1HTTPOLBCXCR2
SCHEMBL4364985 0.70 SMN1; SMN2 (0.38) ADAMTS5HTTNR3C2POLBCXCR2
SCHEMBL4366400 0.70 CXCR2 (0.40) ADAMTS5NR3C2CXCR2
SCHEMBL4370733 0.70 MAPKAPK2 (0.38) ADAMTS5NR3C2CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed