Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 14/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370733 | 0.86 | MAPKAPK2 (0.38) | CXCR2ADAMTS5MAPKAPK2NR3C2PDGFRA | |
| SCHEMBL4370003 | 0.83 | MAPKAPK2 (0.50) | CXCR2ADAMTS5MAPKAPK2NR3C2PDGFRA | |
| SCHEMBL4364985 | 0.74 | SMN1; SMN2 (0.38) | CXCR2ADAMTS5NR3C2MAPK1ALDH1A1 | |
| SCHEMBL8768875 | 0.72 | CXCR2 (0.43) | CXCR2ADAMTS5NR3C2 | |
| SCHEMBL4366404 | 0.70 | FES (0.56) | CXCR2MAPKAPK2AURKBCSNK1G1 | |
| SCHEMBL8769026 | 0.70 | ADAMTS5 (0.46) | CXCR2ADAMTS5NR3C2 | |
| SCHEMBL8768157 | 0.66 | CXCR2 (0.45) | CXCR2ALDH1A1 | |
| SCHEMBL8767798 | 0.66 | ABCC9 (0.53) | CXCR2ADAMTS5NR3C2ALDH1A1 | |
| SCHEMBL8768638 | 0.64 | ADAMTS5 (0.44) | CXCR2ADAMTS5 | |
| SCHEMBL9381224 | 0.60 | MAPT (0.56) | NR3C2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |