Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768638 | 0.90 | ADAMTS5 (0.44) | CXCR2ADAMTS5CRHBPCRHR2KDM1A | |
| SCHEMBL8768608 | 0.89 | RORC (0.40) | CXCR2ADAMTS5KDM1ARORC | |
| SCHEMBL8767825 | 0.87 | CXCR2 (0.44) | CXCR2CRHBPCRHR2MAPTNPSR1 | |
| SCHEMBL8768956 | 0.86 | ADAMTS5 (0.46) | ADAMTS5MAPTNPSR1 | |
| SCHEMBL8767671 | 0.84 | CXCR2 (0.45) | CXCR2ADAMTS5MAPTNPSR1ABCG2 | |
| SCHEMBL8767798 | 0.82 | ABCC9 (0.53) | CXCR2ADAMTS5CRHBPCRHR2MAPT | |
| SCHEMBL8768157 | 0.82 | CXCR2 (0.45) | CXCR2CRHBPCRHR2MAPTNPSR1 | |
| SCHEMBL4370003 | 0.81 | MAPKAPK2 (0.50) | CXCR2ADAMTS5NR3C2 | |
| SCHEMBL8769026 | 0.77 | ADAMTS5 (0.46) | CXCR2ADAMTS5MAPTNR3C2 | |
| SCHEMBL151094 | 0.74 | CRHBP (0.56) | CRHBPCRHR2MAPTNPSR1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789690-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-08-20 | — | — | EP | claimed |
| WO-1996014300-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-17 | — | — | WO | claimed |