SCHEMBL4364985

SCHEMBL4364985

CCN(c1ccccc1)c1c(Nc2cncc(Br)c2)c(=O)c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
MAPK1 P28482 2/20 0.38
HTT P42858 2/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
GRM5 P41594 1/20 0.38
NR3C2 P08235 1/20 0.35
CXCR2 P25025 1/20 0.35
ALOX15 P16050 1/20 0.35
ALDH1A1 P00352 1/20 0.34
ADAMTS5 Q9UNA0 1/20 0.34
HDAC4 P56524 1/20 0.33
SLC22A12 Q96S37 1/20 0.33
POLB P06746 1/20 0.33
KDM4C Q9H3R0 1/20 0.33
APAF1 O14727 1/20 0.33
CASP3 P42574 1/20 0.33
CASP6 P55212 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4370003 0.80 MAPKAPK2 (0.50) MAPK1NR3C2CXCR2ADAMTS5KDR
SCHEMBL4366400 0.74 CXCR2 (0.40) MAPK1NR3C2CXCR2ALDH1A1ADAMTS5
SCHEMBL4370733 0.74 MAPKAPK2 (0.38) MAPK1NR3C2CXCR2ALDH1A1ADAMTS5
SCHEMBL8768875 0.72 CXCR2 (0.43) MAPTNR3C2CXCR2ADAMTS5
SCHEMBL8767825 0.72 CXCR2 (0.44) SMN1; SMN2MAPK1HTTMAPTGRM5
SCHEMBL8995740 0.70 MAPKAPK2 (0.64) MAPK1
SCHEMBL8870913 0.70 MAPKAPK2 (0.64) MAPK1
SCHEMBL4364986 0.70 FES (0.53) SMN1; SMN2CXCR2POLBKDM4CKDR
SCHEMBL8769026 0.70 ADAMTS5 (0.46) SMN1; SMN2NPC1RAB9AHTTMAPT
SCHEMBL8995732 0.69 POLB (0.50) SMN1; SMN2NPC1RAB9AMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009012375-A2 SQUARATE KINASE INHIBITORS WYETH (US) 2009-01-22 WO claimed
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed
WO-2009012375-A2 SQUARATE KINASE INHIBITORS WYETH (US) 2009-01-22 WO disclosed
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP disclosed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO disclosed