Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GOT1 | P17174 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088854 | 0.75 | NOS2 (0.39) | POLBP2RX7GAANOS3NOS2 | |
| SCHEMBL31097846 | 0.75 | NOS2 (0.39) | POLBP2RX7GAANOS3NOS2 | |
| SCHEMBL7690225 | 0.74 | ALDH1A1 (0.36) | ALDH1A1POLBTDP1L3MBTL1MAPT | |
| SCHEMBL18940676 | 0.74 | AXL (0.36) | ALDH1A1POLBTDP1MAPTKDM4E | |
| SCHEMBL364870 | 0.74 | P2RX7 (0.36) | POLBP2RX7NOS3NOS2PIK3CD | |
| SCHEMBL30147779 | 0.74 | AXL (0.36) | ALDH1A1POLBTDP1MAPTKDM4E | |
| SCHEMBL358590 | 0.73 | ALDH1A1 (0.47) | ALDH1A1POLBTDP1L3MBTL1MAPT | |
| SCHEMBL29564876 | 0.73 | ALDH1A1 (0.47) | ALDH1A1POLBTDP1L3MBTL1MAPT | |
| SCHEMBL6805218 | 0.72 | AAK1 (0.38) | TDP1P2RX7NOS3NOS2PIK3CD | |
| SCHEMBL22056622 | 0.71 | P2RX7 (0.38) | ALDH1A1POLBTDP1L3MBTL1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |