Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442249 | 0.88 | NPC1 (0.41) | NPC1RAB9ATP53GMNNUSP2 | |
| SCHEMBL440348 | 0.82 | NPC1 (0.44) | NPC1RAB9ATP53GMNNUSP2 | |
| SCHEMBL440060 | 0.80 | BCHE (0.50) | LMNAMAPTCDK2CLK1NPSR1 | |
| SCHEMBL441848 | 0.78 | KMT2A (0.55) | TP53LMNACYP1A2CYP3A4ALOX15 | |
| SCHEMBL30880730 | 0.77 | TRPV1 (0.43) | NPC1RAB9ATP53GMNNUSP2 | |
| SCHEMBL439770 | 0.77 | BACE1 (0.42) | CYP1A2CYP3A4CYP2C9SCN4ASMN1; SMN2 | |
| SCHEMBL2209996 | 0.77 | TRPV1 (0.43) | NPC1RAB9ATP53GMNNUSP2 | |
| Hydrochloric Acid SCHEMBL30880572 | 0.76 | NPC1 (0.42) | NPC1RAB9ATP53GMNNUSP2 | |
| SCHEMBL29366167 | 0.75 | DDR1 (0.44) | NPC1RAB9ATP53GMNNUSP2 | |
| SCHEMBL22589620 | 0.75 | DDR1 (0.44) | NPC1RAB9ATP53GMNNUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |