Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369133 | 0.87 | TSHR (0.49) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL12195183 | 0.85 | KEAP1 (0.52) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL1003119 | 0.85 | OPRD1 (0.52) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL1002715 | 0.84 | PKM (0.55) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL4832144 | 0.83 | OPRD1 (0.51) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL4832360 | 0.83 | TSHR (0.46) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL8512562 | 0.82 | OPRD1 (0.53) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL4832353 | 0.82 | OPRD1 (0.46) | TSHRALOX15ATMOPRD1OPRK1 | |
| SCHEMBL2465494 | 0.81 | TP53 (0.52) | TSHRALOX15ATMTACR1ACHE | |
| SCHEMBL2375438 | 0.81 | GPR119 (0.50) | TSHRALOX15ATMOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077941-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2009-08-12 | — | — | EP | disclosed |
| US-6303620-B1 | USED FOR THERAPY OF MEDICAL DISORDERS RESULTING FROM A DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2001-10-16 | — | — | US | disclosed |