Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.31 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7174227 | 0.93 | CA2 (0.34) | MMP2MMP9CA2CA4HPGDS | |
| SCHEMBL4374530 | 0.93 | MMP2 (0.36) | MMP2MMP9HPGDSMMP1MAP4K4 | |
| SCHEMBL3871098 | 0.86 | HPGDS (0.37) | MMP2MMP9HPGDSMAP4K4 | |
| SCHEMBL1797052 | 0.86 | F2 (0.37) | POLBMAP4K4WNT3A | |
| SCHEMBL4377641 | 0.86 | MMP2 (0.40) | MMP2MMP9HPGDSSCN9AMMP1 | |
| SCHEMBL4372216 | 0.82 | MMP2 (0.37) | MMP2MMP9ITGB3ITGA2BSCN9A | |
| SCHEMBL1798434 | 0.81 | ADAM17 (0.43) | MMP2MMP9ADAMTS4MMP1ADAM17 | |
| SCHEMBL4371607 | 0.80 | MMP2 (0.44) | MMP2MMP9ITGB3ITGA2B | |
| SCHEMBL4297273 | 0.78 | CA2 (0.39) | CA2CA4HPGDSSCN9APIK3CD | |
| SCHEMBL4373799 | 0.75 | MMP2 (0.38) | MMP2MMP9CA2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |