Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880329 | 0.81 | MMP13 (0.39) | MAPK1MMP1MMP13MMP2MMP3 | |
| SCHEMBL1803718 | 0.78 | ADAM17 (0.39) | MAPK1MMP1MMP2MMP9MMP14 | |
| SCHEMBL3870206 | 0.78 | ALDH1A1 (0.43) | MAPK1MMP1MMP13MMP2MMP3 | |
| SCHEMBL1798436 | 0.77 | ADAMTS7 (0.46) | MMP13SCN9A | |
| SCHEMBL1798439 | 0.77 | ADAMTS7 (0.46) | MMP13SCN9A | |
| SCHEMBL1798308 | 0.77 | MMP1 (0.49) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL1798306 | 0.77 | MMP1 (0.49) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL1801848 | 0.76 | MAPK1 (0.47) | MAPK1ALDH1A1SCN9AKMT2ALMNA | |
| SCHEMBL1796851 | 0.76 | ADAM17 (0.59) | MMP1MMP2MMP9MMP14ADAM17 | |
| SCHEMBL4370904 | 0.74 | ADAM17 (0.51) | MMP1MMP2MMP9MMP14ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |