Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 16/20 | 0.38 |
| ▸ | CTSD | P07339 | 12/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376938 | 0.91 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4383634 | 0.90 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL4374524 | 0.87 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4583485 | 0.87 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4373508 | 0.87 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4378945 | 0.84 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4375391 | 0.82 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL4371837 | 0.82 | HTR2A (0.40) | ALDH1A1LMNABACE1CTSDBACE2 | |
| SCHEMBL4380618 | 0.80 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL4562968 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |