Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373196 | 0.90 | ALDH1A1 (0.45) | ALDH1A1LMNA | |
| SCHEMBL4583485 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNACCR1MEN1KMT2A | |
| SCHEMBL4374524 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNACCR1MEN1KMT2A | |
| SCHEMBL4376938 | 0.89 | ALDH1A1 (0.44) | ALDH1A1LMNACTSSCTSKAKT1 | |
| SCHEMBL4371837 | 0.89 | HTR2A (0.40) | ALDH1A1LMNAPIN1AKT1AKT2 | |
| SCHEMBL4373508 | 0.87 | ALDH1A1 (0.42) | ALDH1A1LMNAPIN1ROCK1PRKCA | |
| SCHEMBL4375391 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNACTSSCTSKCCR1 | |
| SCHEMBL4378945 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAGSK3BPPARGKMT2A | |
| SCHEMBL4544087 | 0.81 | AKT1 (0.39) | ROCK1GRM5CCR1CHRM2CCR5 | |
| SCHEMBL4380618 | 0.80 | ALDH1A1 (0.41) | ALDH1A1LMNAAKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |