Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583485 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2KMT2APYGL | |
| SCHEMBL4374524 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2KMT2APYGL | |
| SCHEMBL4376938 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2MMEACE | |
| SCHEMBL4373508 | 0.88 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2BCHEACHE | |
| SCHEMBL4562968 | 0.87 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL4374076 | 0.87 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL4373196 | 0.84 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4383634 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNAPPARGKMT2AGSK3B | |
| SCHEMBL4371837 | 0.81 | HTR2A (0.40) | ALDH1A1LMNABCHE | |
| SCHEMBL4375391 | 0.80 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |