Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374524 | 1.00 | ALDH1A1 (0.47) | ALDH1A1LMNABCHEACHEHPGD | |
| SCHEMBL4376938 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4378945 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNABCHEACHEPYGL | |
| SCHEMBL4383634 | 0.90 | ALDH1A1 (0.41) | ALDH1A1LMNAKMT2ACCR1MEN1 | |
| SCHEMBL4371837 | 0.88 | HTR2A (0.40) | ALDH1A1LMNABCHECTSLL3MBTL1 | |
| SCHEMBL4373196 | 0.87 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4373508 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNABCHEACHESMN1; SMN2 | |
| SCHEMBL4375391 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNAHPGDCTSLSMN1; SMN2 | |
| SCHEMBL4380618 | 0.86 | ALDH1A1 (0.41) | ALDH1A1LMNAHPGDKMT2AMEN1 | |
| SCHEMBL4378512 | 0.83 | AKT1 (0.40) | ALDH1A1LMNAHPGDPYGLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |