SCHEMBL4373398

SCHEMBL4373398

CCn1c2c(c3ccccc31)-c1ccccc1C2N([SiH](C)C)C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.35
KDM4E B2RXH2 9/20 0.34
RCE1 Q9Y256 1/20 0.34
MAPT P10636 7/20 0.34
HSD17B10 Q99714 4/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPK1 P28482 2/20 0.34
HTT P42858 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
HPGD P15428 2/20 0.34
HBB P68871 1/20 0.34
LMNA P02545 2/20 0.33
TSHR P16473 2/20 0.32
NPY1R P25929 1/20 0.32
NPY2R P49146 1/20 0.32
NSD2 O96028 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
PER2 O15055 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7510360 0.72 GPR3 (0.50) MEN1KMT2A
SCHEMBL4373543 0.70 ALDH1A1 (0.44) ALDH1A1KDM4EMAPTHSD17B10MEN1
SCHEMBL5041930 0.70 MEN1 (0.32) ALDH1A1KDM4ERCE1MAPTHSD17B10
SCHEMBL4375149 0.67 GPR3 (0.36)
SCHEMBL7630742 0.66 GPR3 (0.39)
SCHEMBL7128408 0.61 GPR3 (0.40) ALDH1A1KDM4EMAPTHSD17B10MEN1
SCHEMBL7634050 0.60
SCHEMBL29963695 0.59 ALDH1A1 (0.75) ALDH1A1KDM4ERCE1MAPTHSD17B10
SCHEMBL29360167 0.59 ALDH1A1 (0.75) ALDH1A1KDM4ERCE1MAPTHSD17B10
SCHEMBL151563 0.59 ALDH1A1 (0.75) ALDH1A1KDM4ERCE1MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1533324-B1 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method BASELL POLYOLEFINE GMBH (DE) 2009-05-06 EP disclosed
EP-1533324-A2 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method Basell Polyolefine GmbH (DE) 2005-05-25 EP disclosed
EP-1159310-B1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL POLYOLEFINE GMBH (DE) 2005-03-30 EP disclosed
US-6730754-B2 COORDINATION POLYMERIZATION CATALYST BASELL POLYOLEFINE GMBH (DE) 2004-05-04 US disclosed
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers EQUISTAR CHEMICALS, LP 2002-10-10 US disclosed
EP-1159310-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS Basell Technology Company B.V. (NL) 2001-12-05 EP disclosed
WO-2001053360-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers GRB7, CHRM1, CPNE4 ALDH1A1 4259/4885KDM4E 4193/4885RCE1 2137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.