Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 8/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373433 | 0.91 | ALDH1A1 (0.40) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4372670 | 0.89 | CNR1 (0.42) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4376045 | 0.86 | TSHR (0.42) | TSHRCNR2KMT2AALDH1A1GAA | |
| SCHEMBL4379995 | 0.84 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4380421 | 0.84 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4373529 | 0.82 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4383359 | 0.78 | RORC (0.46) | TSHRCNR2KMT2AMAPTALDH1A1 | |
| SCHEMBL4368598 | 0.77 | CNR2 (0.42) | TSHRCNR2 | |
| SCHEMBL4374742 | 0.77 | TSHR (0.42) | TSHRCNR2ALDH1A1GAAKDM4E | |
| SCHEMBL4380542 | 0.77 | KMT2A (0.44) | TSHRKMT2AGRIN1GRIN2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |