Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375382 | 0.77 | CYP2C19 (0.41) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL4583697 | 0.74 | KMT2A (0.48) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL28650967 | 0.73 | CA12 (0.50) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL16266052 | 0.71 | CA12 (0.47) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL28655810 | 0.70 | CA12 (0.55) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL4374146 | 0.69 | KMT2A (0.41) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL6389352 | 0.69 | CA12 (0.49) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL10507444 | 0.69 | CA12 (0.52) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL14908703 | 0.68 | CA12 (0.42) | CA12CA9KMT2AMEN1RAB9A | |
| SCHEMBL13484325 | 0.68 | ALDH1A1 (0.52) | CA12CA9KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-2114388-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008098105-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |