SCHEMBL437422

SCHEMBL437422

Cn1nc(C(F)F)c(C(=O)O)c1F

nearest known ligand 0.37

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.37
PTGER2 P43116 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28753862 0.98 PTGER4 (0.37) PTGER4PTGER2MEN1KMT2A
SCHEMBL15237109 0.85 PTGER4 (0.33) PTGER4PTGER2
SCHEMBL434677 0.85 PTGER4 (0.33) PTGER4PTGER2
SCHEMBL406206 0.85 ALDH1A1 (0.33) PTGER4MEN1KMT2A
SCHEMBL13723232 0.84 PTGER4 (0.34) PTGER4PTGER2
SCHEMBL439648 0.84 PTGER4 (0.33) PTGER4
SCHEMBL9373962 0.83 L3MBTL1 (0.42) PTGER4MEN1KMT2A
SCHEMBL15165797 0.81 PTGER4 (0.35) PTGER4PTGER2MEN1KMT2A
SCHEMBL3401329 0.81 KDM4E (0.40) PTGER4PTGER2MEN1KMT2A
SCHEMBL20996474 0.80 PTGER4 (0.34) PTGER4PTGER2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119504589-A Method for synthesizing Isoflucypram intermediate 山西玉龙化工有限公司 2025-02-25 CN claimed
EP-2560961-B1 METHOD FOR PRODUCING 5-FLUOR-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOL-4-CARBOXYLIC ACID AND CHLORIDES AND FLUORIDES BAYER IP GMBH (DE) 2016-11-16 EP claimed
CN-119954721-A Pyrazole amide derivative, preparation method and application thereof 山东省联合农药工业有限公司 2025-05-09 CN disclosed
CN-119504589-A Method for synthesizing Isoflucypram intermediate 山西玉龙化工有限公司 2025-02-25 CN disclosed
CN-119504589-A Method for synthesizing Isoflucypram intermediate 山西玉龙化工有限公司 2025-02-25 CN disclosed
CN-114450269-A Novel method for synthesizing 5-fluoro-3- (difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivative and free acid thereof 福建永晶科技股份有限公司 2022-05-06 CN disclosed
EP-3000809-B1 FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES BAYER IP GMBH (DE) 2018-10-31 EP disclosed
US-10098350-B2 Fungicidal amides FMC CORPORATION 2018-10-16 US disclosed
US-9951023-B2 Process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbaldehyde BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-24 US disclosed
US-9951023-B2 Process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbaldehyde BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-24 US disclosed
US-9951023-B2 Process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbaldehyde BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-24 US disclosed
US-20110207940-A1 Preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides BAYER CROPSCIENCE AG (DE) 2011-08-25 US disclosed
US-20110207940-A1 Preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides BAYER CROPSCIENCE AG (DE) 2011-08-25 US disclosed
WO-2011061205-A1 METHOD FOR PRODUCING 5-FLUORINE-1-ALKYL-3-FLUORALKYL-1H-PYRAZOL-4 CARBOLIC ACID CHLORIDES BAYER CROPSCIENCE AG (DE) 2011-05-26 WO disclosed
EP-2325173-A1 Method for producing 5-fluor-1-alkyl-3-fluoralkyl-1H-pyrazol-4-carboxylic acid chlorides Bayer CropScience AG (DE) 2011-05-25 EP disclosed
WO-2010130767-A2 FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-11-18 WO disclosed
EP-2251331-A1 Fungicide pyrazole carboxamides derivatives Bayer CropScience AG (DE) 2010-11-17 EP disclosed
EP-0623113-B1 PYRAZOLE CARBOXANILIDE FUNGICIDES MONSANTO CO (US) 1997-03-05 EP disclosed
US-5223526-A For plants MONSANTO COMPANY (US) 1993-06-29 US disclosed
WO-1993011117-A1 PYRAZOLE CARBOXANILIDE FUNGICIDES MONSANTO COMPANY (US) 1993-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110207940-A1 Preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides CBR3, CYP4B1, CYP4F3 PTGER4 4711/4885PTGER2 4881/4885MEN1 1522/4885
US-10098350-B2 Fungicidal amides CBR1, CBR3, PRXL2A PTGER4 2677/4885PTGER2 1863/4885MEN1 2386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.