Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.32 |
| ▸ | CCR3 | P51677 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AOC2 | O75106 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360161 | 0.81 | FAAH (0.36) | HRH3FAAHHRH1CCR3KCNH2 | |
| SCHEMBL4019345 | 0.76 | HRH3 (0.43) | HRH3KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4202808 | 0.71 | HRH3 (0.46) | HRH3SLC6A4 | |
| SCHEMBL4031484 | 0.70 | SLC6A2 (0.47) | HRH3NPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18389811 | 0.66 | L3MBTL1 (0.50) | HRH3KCNH2NPSR1 | |
| SCHEMBL4014475 | 0.65 | SLC6A4 (0.60) | HRH3KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17897282 | 0.64 | ALDH1A1 (0.52) | DPP4 | |
| SCHEMBL4011831 | 0.60 | SLC6A4 (0.43) | HRH3FAAHCCR3KCNH2SLC6A2 | |
| SCHEMBL17897283 | 0.60 | TRPC5 (0.48) | — | |
| SCHEMBL7164782 | 0.60 | KDM1A (0.51) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049473-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008002820-A2 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | disclosed |