Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNLIP | P16233 | 8/20 | 0.81 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | FADS1 | O60427 | 1/20 | 0.59 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365186 | 0.86 | FFAR1 (0.66) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL19772402 | 0.86 | PNLIP (0.61) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL13927140 | 0.86 | MAPK1 (0.79) | PNLIPMEN1KMT2ALMNAPOLB | |
| Osalmid SCHEMBL10526328 | 0.84 | PNLIP (0.88) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL18327173 | 0.82 | MEN1 (0.79) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL4366516 | 0.82 | PNLIP (0.58) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL18327174 | 0.80 | LMNA (0.89) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL14514567 | 0.80 | PNLIP (0.74) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL8406630 | 0.80 | P2RX1 (0.75) | PNLIPMEN1KMT2ALMNAKDM4E | |
| SCHEMBL28470212 | 0.79 | FADS1 (0.59) | PNLIPMEN1KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20050187300-A1 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INCORPORATED (US) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187300-A1 | Compounds, compositions, and methods employing same | HMGCR, APOB, PCSK9 | PNLIP 5/4885MEN1 428/4885KMT2A 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.