Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264571 | 0.78 | MAPK1 (0.39) | SCN9AMMP2MMP9ALDH1A1 | |
| SCHEMBL1796851 | 0.77 | ADAM17 (0.59) | MMP2MMP9 | |
| SCHEMBL3869082 | 0.76 | MMP2 (0.42) | SCN9AMMP2MMP9 | |
| SCHEMBL4370904 | 0.76 | ADAM17 (0.51) | MMP2MMP9 | |
| SCHEMBL4372240 | 0.73 | MMP2 (0.41) | SCN9AMMP2MMP9 | |
| SCHEMBL1802607 | 0.71 | MMP2 (0.52) | SCN9AMMP2MMP9 | |
| SCHEMBL1798439 | 0.71 | ADAMTS7 (0.46) | SCN9A | |
| SCHEMBL1798436 | 0.71 | ADAMTS7 (0.46) | SCN9A | |
| SCHEMBL1798308 | 0.70 | MMP1 (0.49) | SCN9AMMP2MMP9ALDH1A1 | |
| SCHEMBL1798306 | 0.70 | MMP1 (0.49) | SCN9AMMP2MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |