Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024118 | 0.89 | HSPB1 (0.50) | HSPB1MAPK14ALDH1A1CYP3A4TSHR | |
| SCHEMBL31287801 | 0.89 | HSPB1 (0.50) | HSPB1MAPK14ALDH1A1CYP3A4TSHR | |
| SCHEMBL21104547 | 0.88 | ALDH1A1 (0.52) | HSPB1MAPK14ALDH1A1CYP3A4TSHR | |
| SCHEMBL13857904 | 0.85 | ALDH1A1 (0.48) | HSPB1ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL10561428 | 0.81 | MAPT (0.57) | HSPB1ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL1371520 | 0.81 | ALDH1A1 (0.48) | HSPB1ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL14965170 | 0.81 | MAOA (0.57) | ALDH1A1CYP3A4TSHRTDP1MEN1 | |
| SCHEMBL21186209 | 0.81 | PDE7A (0.56) | ALDH1A1CYP3A4TSHRTDP1NCOA1 | |
| SCHEMBL31264488 | 0.81 | PDE7A (0.56) | ALDH1A1CYP3A4TSHRTDP1NCOA1 | |
| SCHEMBL4372913 | 0.81 | HSPB1 (0.58) | HSPB1MAPK14SCN4AARTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084056-A1 | SUBSTITUTED OXOISOINDOLINYL PIPERIDINE-2,6-DIONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-03-13 | — | — | US | disclosed |
| US-20220213092-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | ABBVIE INC (US) | 2022-07-07 | — | — | US | disclosed |
| WO-2022132997-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | ABBVIE INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| US-20200247808-A1 | Heterocyclic Tec-Family Kinase Inhibitors | GB005, INC. | 2020-08-06 | — | — | US | disclosed |
| WO-2019141980-A1 | AGRICULTURAL CHEMICALS | GLOBACHEM NV (BE) | 2019-07-25 | — | — | WO | disclosed |
| WO-2017041180-A1 | HETEROCYCLIC TEC-FAMILY KINASE INHIBITORS | PHARMASCIENCE INC. (CA) | 2017-03-16 | — | — | WO | disclosed |
| US-7625932-B2 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625932-B2 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625932-B2 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | disclosed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247808-A1 | Heterocyclic Tec-Family Kinase Inhibitors | TEC, BTK, LCK | HSPB1 2608/4885MAPK14 262/4885ALDH1A1 4469/4885 |
| US-20250084056-A1 | SUBSTITUTED OXOISOINDOLINYL PIPERIDINE-2,6-DIONE COMPOUNDS | CCNA1, CCNI, CCNE1 | HSPB1 2029/4885MAPK14 2446/4885ALDH1A1 431/4885 |
| US-20220213092-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | BTK, LYN, ABL1 | HSPB1 4429/4885MAPK14 869/4885ALDH1A1 3541/4885 |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | GRIN1, GRIN3A, GRIK5 | HSPB1 4378/4885MAPK14 1837/4885ALDH1A1 2211/4885 |
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | HSPB1 3201/4885MAPK14 3282/4885ALDH1A1 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.