Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 9/20 | 0.44 |
| ▸ | MMP13 | P45452 | 9/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.44 |
| ▸ | TARS1 | P26639 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802607 | 0.84 | MMP2 (0.52) | SCN9AMMP1MMP13MMP2MMP9 | |
| SCHEMBL4372267 | 0.84 | BCL2L1 (0.43) | BCL2L1MCL1MMP1MMP13MMP2 | |
| SCHEMBL6472806 | 0.74 | TARS1 (0.50) | BCL2L1MCL1MMP1MMP13MMP2 | |
| SCHEMBL1800019 | 0.74 | MMP2 (0.62) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL4299834 | 0.74 | TACR2 (0.42) | SCN9AMMP13MMP2MMP9MMP14 | |
| SCHEMBL3869082 | 0.73 | MMP2 (0.42) | BCL2L1MCL1SCN9AMMP1MMP13 | |
| SCHEMBL4372240 | 0.72 | MMP2 (0.41) | BCL2L1MCL1SCN9AMMP1MMP13 | |
| SCHEMBL6337882 | 0.72 | ALDH1A1 (0.64) | MMP2SOS1CA1CA2FFAR1 | |
| SCHEMBL1800122 | 0.71 | MMP2 (0.65) | BCL2L1MCL1SCN9AMMP1MMP13 | |
| SCHEMBL4379115 | 0.70 | MMP2 (0.42) | SCN9AMMP1MMP13MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |