Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.41 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 7/20 | 0.40 |
| ▸ | MMP13 | P45452 | 6/20 | 0.40 |
| ▸ | TARS1 | P26639 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.40 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472806 | 0.91 | TARS1 (0.50) | BCL2L1MCL1MMP2MMP9ADAM17 | |
| SCHEMBL4377322 | 0.86 | ADAM17 (0.56) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL4374935 | 0.84 | BCL2L1 (0.47) | BCL2L1MCL1MMP2MMP9MMP12 | |
| SCHEMBL4372036 | 0.82 | SCN9A (0.41) | BCL2L1MCL1MMP2MMP9ADAM17 | |
| SCHEMBL4370904 | 0.77 | ADAM17 (0.51) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL1799177 | 0.77 | BMP1 (0.58) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL1799334 | 0.76 | ADAM17 (0.50) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL14470899 | 0.76 | ADAM17 (0.50) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL1800831 | 0.76 | ADAM17 (0.50) | MMP2MMP9ADAM17ADAM10ADAM8 | |
| SCHEMBL1801064 | 0.75 | MMP2 (0.49) | MMP2MMP9ADAM17ADAM10ADAM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |