Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 9/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | MMP13 | P45452 | 5/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | BMP1 | P13497 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372267 | 0.91 | BCL2L1 (0.43) | TARS1BCL2L1MCL1MMP2CA12 | |
| SCHEMBL4372036 | 0.87 | SCN9A (0.41) | TARS1BCL2L1MCL1MMP2CA12 | |
| SCHEMBL1799177 | 0.86 | BMP1 (0.58) | MMP2MMP13MMP14ADAMTS4ADAMTS5 | |
| SCHEMBL1801064 | 0.84 | MMP2 (0.49) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL8358421 | 0.82 | BMP1 (0.54) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL8358332 | 0.82 | MMP2 (0.47) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL4377322 | 0.77 | ADAM17 (0.56) | MMP2MMP13MMP14ADAMTS4ADAMTS5 | |
| SCHEMBL12619403 | 0.76 | BMP1 (0.61) | MMP2MMP13MMP14BMP1MMP1 | |
| SCHEMBL4374935 | 0.74 | BCL2L1 (0.47) | TARS1BCL2L1MCL1MMP2CA1 | |
| SCHEMBL1799173 | 0.74 | MMP2 (0.41) | MMP2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227973-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227973-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, ADAM9 | TARS1 2165/4885BCL2L1 512/4885MCL1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.