Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114259 | 0.93 | FFAR4 (0.50) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| SCHEMBL8153854 | 0.93 | TSHR (0.48) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| SCHEMBL2141472 | 0.93 | HDAC1 (0.41) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| SCHEMBL5475791 | 0.91 | FFAR4 (0.53) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| Ethylene Glycol SCHEMBL4914065 | 0.88 | FFAR4 (0.46) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| SCHEMBL2839365 | 0.86 | FFAR4 (0.46) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 | |
| SCHEMBL5712400 | 0.85 | LMNA (0.48) | ALDH1A1TSHRTDP1MEN1KMT2A | |
| SCHEMBL11652184 | 0.85 | LMNA (0.53) | ALDH1A1TSHRTDP1MEN1KMT2A | |
| SCHEMBL2706936 | 0.85 | LMNA (0.42) | ALDH1A1TSHRTDP1LMNA | |
| SCHEMBL4667879 | 0.84 | FFAR4 (0.53) | FFAR4FFAR1ALDH1A1AKR1B1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541057-B2 | Cyclohexane oxidation process byproduct derivatives and methods for using the same | INVISTA NORTH AMERICA S.A R.L. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120101009-A1 | CYCLOHEXANE OXIDATION PROCESS BYPRODUCT STREAM DERIVATIVES AND METHODS FOR USING THE SAME | INVISTA NORTH AMERICA S.A.R.L. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20120064252-A1 | CYCLOHEXANE OXIDATION PROCESS BYPRODUCT DERIVATIVES AND METHODS FOR USING THE SAME | INVISTA NORTH AMERICA S.A.R.L. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101009-A1 | CYCLOHEXANE OXIDATION PROCESS BYPRODUCT STREAM DERIVATIVES AND METHODS FOR USING THE SAME | DECR1, SIGMAR1, NOP2 | FFAR4 84/4885FFAR1 6/4885ALDH1A1 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.