Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370906 | 0.93 | SCN9A (0.36) | TBXA2RSCN9ACA12CA1CA2 | |
| SCHEMBL4371687 | 0.91 | SMN1; SMN2 (0.36) | SCN9ACA12CA1CA2CA9 | |
| SCHEMBL1800587 | 0.90 | SLC9A3 (0.33) | CA12CA1CA2CA9PSEN1 | |
| SCHEMBL4372245 | 0.89 | TBXA2R (0.39) | TBXA2RSCN9APSEN1PSEN2APH1B | |
| SCHEMBL1804010 | 0.88 | CARM1 (0.35) | TBXA2RCA12CA1CA2CA9 | |
| SCHEMBL4377327 | 0.83 | F2 (0.39) | CA12CA1CA2CA9SOS1 | |
| SCHEMBL1799336 | 0.82 | F2 (0.34) | CA12CA1CA2CA9PRSS1 | |
| SCHEMBL1798846 | 0.82 | DAGLA (0.38) | SCN9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3874559 | 0.82 | NPY4R (0.36) | — | |
| SCHEMBL1799060 | 0.81 | SLC9A3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |