Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 6/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP14 | P50281 | 3/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370906 | 0.93 | SCN9A (0.36) | CA2SCN9APRSS1TMPRSS15CA12 | |
| SCHEMBL4375795 | 0.91 | TBXA2R (0.34) | CA2SCN9APRSS1TMPRSS15CA12 | |
| SCHEMBL1804010 | 0.90 | CARM1 (0.35) | CA2PRSS1TMPRSS15CA12CA1 | |
| SCHEMBL4293042 | 0.89 | LTA4H (0.33) | CA2CA4MMP2MMP9MMP14 | |
| SCHEMBL4372245 | 0.89 | TBXA2R (0.39) | SCN9AEGLN2 | |
| SCHEMBL4375791 | 0.87 | MMP2 (0.42) | CA2MMP2MMP9MMP14MMP3 | |
| SCHEMBL4377327 | 0.82 | F2 (0.39) | SMN1; SMN2CA2MMP2MMP9MMP14 | |
| SCHEMBL1799336 | 0.82 | F2 (0.34) | CA2PRSS1CA12CA1CA9 | |
| SCHEMBL4372334 | 0.82 | LTA4H (0.40) | MMP2MMP9MMP14MMP13MMP12 | |
| SCHEMBL3874559 | 0.81 | NPY4R (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |